We are interested in life processes that involve deformation and remodeling of membranes, such as viral infection, cell-cell fusion in fertilization, and secretion of neurotransmitters by exocytosis. In order to gain insight into membrane remodeling in such processes, we use mechanical single-molecule techniques: Optical Tweezers in combination with confocal fluorescence microscopy and Atomic Force Microscopy (AFM). Our research is highly multidisciplinary, combining Biology, Chemistry, Physics and some engineering to modify our tools according to the experimental needs, and we also work in close collaboration with biologists and theorists. Our tools allow us to measure membrane mechanical properties and to explore the interactions between membranes and proteins in bio-mimetic model systems and cells. By such quantitative measurements, we hope to contribute to the understanding of biological processes in which membranes play a central role.
Welcome, Shahar, Ella and Chen! Our team is growing :)
Shahar Goren is a PhD student working on force propagation in fibrous gells, jointly supervised with Dr. Ayelet Lesman from the Department of Mechanical Engineering at TAU. Ella Wolowelsky and Chen Shaharbani are undergraduate students, who will use optical tweezers to study membrane fusion. Happy to have you all in the team!
Dr. Hila Shir-Shapira is a new research associate in the lab, responsible for all molecular biology aspects of our research. Hila obtained her B.Sc. and M.Sc. cum laude at Bar Ilan University, where she also pursued her Ph.D. on regulation of gene expression in the group of Prof. Tamar Juven-Gershon. Happy to have you on board!
We are super excited that our new C-trap, correlative optical tweezers and confocal fluorescence microscopy instrument, is up and running! Thank you LUMICKS for the smooth installation and training and for the nice news item!
1 August 2019
Several positions, including Lab manager, Postdocs, Ph.D. and M.Sc. will become available from July 1st, 2020, more details will be provided soon!
A limited number of Undergraduate and Graduate positions, as well as one postdoc position, will be available from November 1st, 2019, contact us for more details!